Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC024
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-16 18:29
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment old patientt tbl Madopar 250mg 3x1/4, tbl Rivotril 2mg 3x/2

Overall Assessment

non PD

Subject performance similar to non PD population

Clinical context

In the clinical reference population, 26 individuals with a value less than 0.61 were subsequently diagnosed with PD. That is, 61.9% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.61 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 1, 'TN': 2, 'TP': 41, 'FP': 28}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 18, 'TN': 13, 'TP': 24, 'FP': 17}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 28, 'TN': 23, 'TP': 14, 'FP': 7}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 24, 'TN': 17, 'TP': 18, 'FP': 13}

Test Battery Details

Circle

numCircles 7
timePerCircleMean 13.9429
timePerCircleCoV 0.0604699
timePerCircleSlope 0.0127049
meanError 1.1263
tremorFreq 6.15234
tremorRelPower 55.4158
tremorGyroAmpMean 0.0847105
tremorGyroAmpSlope 0.000844869
tremorGyroAmpCoV 0.423186
tremorCoordAmpMean 0.131763
tremorCoordAmpSlope -0.00123295
tremorCoordAmpCoV 0.307345
tremorAccAmpMean 0.140492
tremorAccAmpSlope -0.000847095
tremorAccAmpCoV 0.240623
tremorPcRelVar 0.766744
tremorPcX 0.287338
tremorPcY 0.957829

Circle Segment 1

Duration 12.76 s, Accuracy Estimate 0.909 (lower is better)

Circle Segment 2

Duration 13.28 s, Accuracy Estimate 0.988 (lower is better)

Circle Segment 3

Duration 14.12 s, Accuracy Estimate 0.968 (lower is better)

Circle Segment 4

Duration 15.48 s, Accuracy Estimate 1.229 (lower is better)

Circle Segment 5

Duration 13.92 s, Accuracy Estimate 1.034 (lower is better)

Circle Segment 6

Duration 14.12 s, Accuracy Estimate 1.116 (lower is better)

Circle Segment 7

Duration 13.92 s, Accuracy Estimate 1.641 (lower is better)

Spiral

numSpirals 5
timePerSpiralMean 52.288
timePerSpiralCoV 0.0565744
timePerSpiralSlope 0.0218788
meanError 1.42742
tremorFreq 5.85938
tremorRelPower 51.5811
tremorGyroAmpMean 0.106732
tremorGyroAmpSlope 6.63175e-05
tremorGyroAmpCoV 0.57308
tremorCoordAmpMean 0.111938
tremorCoordAmpSlope -0.00131315
tremorCoordAmpCoV 0.514216
tremorAccAmpMean 0.116172
tremorAccAmpSlope -0.00106097
tremorAccAmpCoV 0.450461
tremorPcRelVar 0.6998
tremorPcX -0.047965
tremorPcY 0.998849

Spiral Segment 1

Duration 48.52 s, Accuracy Estimate 1.501 (lower is better)

Spiral Segment 2

Duration 53.08 s, Accuracy Estimate 1.49 (lower is better)

Spiral Segment 3

Duration 50.8 s, Accuracy Estimate 1.447 (lower is better)

Spiral Segment 4

Duration 56.52 s, Accuracy Estimate 1.41 (lower is better)

Spiral Segment 5

Duration 52.52 s, Accuracy Estimate 1.289 (lower is better)

Elel

eDurationMean 1.27141
eDurationStd 0.197397
eDurationStdnorm 0.155259
eDurationMedian 1.255
eDurationQuartdelta 0.2925
eDurationQuartdeltanorm 0.233068
eDurationKurt 2.75332
eDurationTrenddiff -0.145
eDurationTrendratio 0.891791
eWidthMean 6.69
eWidthStd 1.05296
eWidthStdnorm 0.157393
eWidthMedian 6.669
eWidthQuartdelta 1.25775
eWidthQuartdeltanorm 0.188596
eWidthKurt 3.01339
eWidthTrenddiff -0.117
eWidthTrendratio 0.982759
eHeightMean 12.192
eHeightStd 1.17528
eHeightStdnorm 0.0963974
eHeightMedian 12.051
eHeightQuartdelta 1.5795
eHeightQuartdeltanorm 0.131068
eHeightKurt 3.38428
eHeightTrenddiff 0.819
eHeightTrendratio 1.07
eAspectMean 0.551486
eAspectStd 0.0880061
eAspectStdnorm 0.15958
eAspectMedian 0.542056
eAspectQuartdelta 0.132344
eAspectQuartdeltanorm 0.244151
eAspectKurt 2.63789
eAspectTrenddiff -0.0484813
eAspectTrendratio 0.913811
eSlantMean 0.131191
eSlantStd 0.115272
eSlantStdnorm 0.87866
eSlantMedian 0.139344
eSlantQuartdelta 0.18124
eSlantQuartdeltanorm 1.30066
eSlantKurt 2.2194
eSlantTrenddiff 0.0613181
eRtopMean 0.843549
eRtopStd 0.0749216
eRtopStdnorm 0.0888172
eRtopMedian 0.84127
eRtopQuartdelta 0.103483
eRtopQuartdeltanorm 0.123008
eRtopKurt 2.17505
eRtopTrenddiff 0.075
eRbotMean 0.613236
eRbotStd 0.153725
eRbotStdnorm 0.250678
eRbotMedian 0.612903
eRbotQuartdelta 0.25822
eRbotQuartdeltanorm 0.421306
eRbotKurt 1.9416
eRbotTrenddiff 0.0270968
eRrightMean 0.895607
eRrightStd 0.0587337
eRrightStdnorm 0.0655798
eRrightMedian 0.88785
eRrightQuartdelta 0.095249
eRrightQuartdeltanorm 0.10728
eRrightKurt 2.20596
eRrightTrenddiff 0.0218919
eRleftMean 0.334584
eRleftStd 0.105842
eRleftStdnorm 0.316339
eRleftMedian 0.309091
eRleftQuartdelta 0.156506
eRleftQuartdeltanorm 0.506343
eRleftKurt 2.1658
eRleftTrenddiff -0.0823529
lDurationMean 1.49462
lDurationStd 0.209427
lDurationStdnorm 0.14012
lDurationMedian 1.46
lDurationQuartdelta 0.2375
lDurationQuartdeltanorm 0.162671
lDurationKurt 3.45106
lDurationTrenddiff -0.125
lDurationTrendratio 0.918699
lWidthMean 10.7903
lWidthStd 1.42792
lWidthStdnorm 0.132333
lWidthMedian 10.647
lWidthQuartdelta 2.0475
lWidthQuartdeltanorm 0.192308
lWidthKurt 3.44595
lWidthTrenddiff 0.468
lWidthTrendratio 1.04444
lHeightMean 24.5554
lHeightStd 2.25135
lHeightStdnorm 0.0916846
lHeightMedian 24.2775
lHeightQuartdelta 2.6325
lHeightQuartdeltanorm 0.108434
lHeightKurt 3.20315
lHeightTrenddiff 0.702
lHeightTrendratio 1.02941
lAspectMean 0.439962
lAspectStd 0.0468528
lAspectStdnorm 0.106493
lAspectMedian 0.444964
lAspectQuartdelta 0.0513829
lAspectQuartdeltanorm 0.115476
lAspectKurt 3.70167
lAspectTrenddiff 0.0107819
lAspectTrendratio 1.02436
lSlantMean 0.178536
lSlantStd 0.0665201
lSlantStdnorm 0.372587
lSlantMedian 0.191482
lSlantQuartdelta 0.105054
lSlantQuartdeltanorm 0.548637
lSlantKurt 2.9593
lSlantTrenddiff 0.0014062
lRtopMean 0.833349
lRtopStd 0.0629023
lRtopStdnorm 0.0754813
lRtopMedian 0.832826
lRtopQuartdelta 0.0835712
lRtopQuartdeltanorm 0.100347
lRtopKurt 3.61196
lRtopTrenddiff -0.00134123
lRbotMean 0.435713
lRbotStd 0.112026
lRbotStdnorm 0.257111
lRbotMedian 0.411538
lRbotQuartdelta 0.187275
lRbotQuartdeltanorm 0.455062
lRbotKurt 2.03367
lRbotTrenddiff -0.0485086
lRrightMean 0.877478
lRrightStd 0.0521639
lRrightStdnorm 0.0594475
lRrightMedian 0.8767
lRrightQuartdelta 0.0609274
lRrightQuartdeltanorm 0.0694963
lRrightKurt 3.93115
lRrightTrenddiff 0.0309335
lRleftMean 0.271311
lRleftStd 0.0698479
lRleftStdnorm 0.257446
lRleftMedian 0.272966
lRleftQuartdelta 0.0790833
lRleftQuartdeltanorm 0.289718
lRleftKurt 5.7181
lRleftTrenddiff -0.0568622

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.850101
sumTouchScores 14.4517
meanMovementTime 1.01
numTouches 17
undershootPercentage 0
overshootPercentage 23.5294

FITTS Long Modified

meanTouchScore 0.911642
sumTouchScores 12.763
meanMovementTime 1.21192
numTouches 14
undershootPercentage 7.14286
overshootPercentage 0

ZigZag

numZigzags 5
timePerZigzagMean 33.648
timePerZigzagCoV 0.098099
timePerZigzagSlope -0.010699
meanError 1.61578
tremorFreq 5.76172
tremorRelPower 44.9941
tremorGyroAmpMean 0.0968249
tremorGyroAmpSlope 0.00098299
tremorGyroAmpCoV 0.509082
tremorCoordAmpMean 0.194477
tremorCoordAmpSlope -0.000259716
tremorCoordAmpCoV 0.425178
tremorAccAmpMean 0.204779
tremorAccAmpSlope -0.000186063
tremorAccAmpCoV 0.331285
tremorPcRelVar 0.841527
tremorPcX 0.36815
tremorPcY 0.929766

ZigZag Segment 1

Duration 37.56 s, Accuracy Estimate 1.436 (lower is better)

ZigZag Segment 2

Duration 33.04 s, Accuracy Estimate 1.486 (lower is better)

ZigZag Segment 3

Duration 29.32 s, Accuracy Estimate 1.561 (lower is better)

ZigZag Segment 4

Duration 32.08 s, Accuracy Estimate 1.776 (lower is better)

ZigZag Segment 5

Duration 36.24 s, Accuracy Estimate 1.819 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 27.248
timePerZigzagCoV 0.190815
timePerZigzagSlope -0.0685555
zigzagHeightMean 70.3516
zigzagHeightCoV 0.058115
zigzagHeightSlope -0.029019
meanError 0.0474646
tremorFreq 5.95703
tremorRelPower 60.9966
tremorGyroAmpMean 0.250982
tremorGyroAmpSlope 0.00387494
tremorGyroAmpCoV 0.550088
tremorCoordAmpMean 0.367082
tremorCoordAmpSlope 0.00125144
tremorCoordAmpCoV 0.45129
tremorAccAmpMean 0.341614
tremorAccAmpSlope 0.00183951
tremorAccAmpCoV 0.428847
tremorPcRelVar 0.926993
tremorPcX 0.108402
tremorPcY -0.994107

ZigZag Offset Segment 1

Duration 27.6 s, Accuracy Estimate 0.032 (lower is better)

ZigZag Offset Segment 2

Duration 36.12 s, Accuracy Estimate 0.065 (lower is better)

ZigZag Offset Segment 3

Duration 23.72 s, Accuracy Estimate 0.036 (lower is better)

ZigZag Offset Segment 4

Duration 24.96 s, Accuracy Estimate 0.025 (lower is better)

ZigZag Offset Segment 5

Duration 23.84 s, Accuracy Estimate 0.078 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.83}
RanFor {‘RanFor_class’: ‘NOT PD’, ‘RanFor_score’: 0.61}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.2341550195925155}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9193717931151606}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5712716869572368}